Methyltrimethoxysilane (MTM) as a Reagent for Direct Amidation of Carboxylic Acids
DOI: 10.14469/hpc/9991 Metadata
Created: 2021-12-14 15:24
Last modified: 2022-01-09 14:09
License: Creative Commons: Public Domain Dedication 1.0
Funding: (none given)
Description
Methyltrimethoxysilane, (MTM, CH3Si(OMe)3) has been demonstrated as an effective, inexpensive and safe reagent for the direct amidation of carboxylic acids with amines. Two simple work-up procedures have been developed that provide the pure amide product without the need for further purification. The first employs an aqueous base mediated annihilation of MTM. A second involves simple product crystallisation from the reaction mixture providing a low process mass intensity direct amidation protocol.
Members
| DOI | Description |
|---|---|
| 10.14469/hpc/9992 | N-(4-Methylbenzyl)-2-phenylacetamide (3) |
| 10.14469/hpc/9993 | 1-Morpholino-2-phenylethan-1-one (4) |
| 10.14469/hpc/9994 | N-Benzyl-N-methyl-2-phenylacetamide (5) |
| 10.14469/hpc/9995 | N-(4-Methylbenzyl)benzamide (6) |
| 10.14469/hpc/9996 | Morpholino(phenyl)methanone (7) |
| 10.14469/hpc/9997 | N-Methyl-N-benzylbenzamide (8) |
| 10.14469/hpc/10006 | N,2-Diphenylacetamide (9) |
| 10.14469/hpc/10008 | N-Phenylbenzamide (10) |
| 10.14469/hpc/10009 | N-Benzyl-2-phenylacetamide (11) |
| 10.14469/hpc/10010 | N-(4-Methylbenzyl)-2-(thiophen-2-yl)acetamide (12) |
| 10.14469/hpc/10011 | 2-Phenyl-1-(piperidin-1-yl)ethan-1-one (13) |
| 10.14469/hpc/10012 | N-Cycloheptylcyclohexanecarboxamide (14) |
| 10.14469/hpc/10013 | (S)-N-(1-Phenylethyl)pivalamide (15) |
| 10.14469/hpc/10014 | N-Hexyl-4-iodobenzamide (16) |
| 10.14469/hpc/10015 | 2-Chloro-N-(4-methylbenzyl)benzamide (17) |
| 10.14469/hpc/10016 | N-(4-Methylbenzyl)hex-5-ynamide (18) |
| 10.14469/hpc/10017 | N-(4-Methylbenzyl)cinnamamide (19) |
| 10.14469/hpc/10018 | N-Octyloctanamide (20) |
| 10.14469/hpc/10019 | N-(4-Methylbenzyl)nicotinamide (21) |
| 10.14469/hpc/10020 | Benzyl (S)-(1-(benzylamino)-1-oxopropan-2-yl)carbamate (22) |
| 10.14469/hpc/10021 | tert-Butyl (S)-(1-(benzylamino)-1-oxopropan-2-yl)carbamate (23) |
| 10.14469/hpc/10022 | N-(4-Methylbenzyl)ferrocene carboxamide (24) |
| 10.14469/hpc/10023 | 2-Amino-N-(4-methylbenzyl)benzamide (25) |
| 10.14469/hpc/10024 | 3-(4-Chlorophenyl)-N-phenylpropanamide (26) |
| 10.14469/hpc/10026 | N1,N3-Bis(4-methylbenzyl)malonamide (27) |
| 10.14469/hpc/10027 | N-Methoxy-N-methyl-2-phenylacetamide (28) |
| 10.14469/hpc/10028 | N-Hexyl-2-hydroxy-2-phenylacetamide (29) |
| 10.14469/hpc/10030 | N,N-Diethyl-2-phenylacetamide (30) |
| 10.14469/hpc/10034 | N-Phenyl-2-(thiophen-2-yl)acetamide (31) |
| 10.14469/hpc/10035 | Benzyl ((S)-1-oxo-1-(((S)-1-phenylethyl)amino)propan-2-yl)carbamate (32) |