COLUMN HEADERS in the files attached are as follows: MarkerName: rsID of variant Allele1: reference allele Allele2: effect allele Freq1: Frequency of the EFFECT allele (ie Allele2) FreqSE: Standard Error of frequency estimate of the effect allele MinFreq: minimum frequency of effect allele MaxFreq: maximum frequency of effect allele Effect: Effect size StdErr: Standard error of effect size estimate P-value: P value of effect (see METAL documentation for more information on Method) Direction: Direction of effect of effect allele with respect to reference allele - ie if Direction is positive (+) then increasing number of copies of Allele 2 increases the trait in question.