Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.
DOI: 10.14469/hpc/7468 Metadata
Created: 2020-10-07 16:28
Last modified: 2020-11-19 13:00
License: Creative Commons: Public Domain Dedication 1.0
Funding: P61446: "Genetic Determinants of Aortic".
Description
Gzipped files containing summary statistics from inverse variance-weighted meta-analysis of 9 LV traits derived from cardiovascular magnetic resonance imaging in UK Biobank. LVEDV= Left Ventricular End-Diastolic Volume LVESV= Left Ventricular End-Systolic Volume LVEF = Left Ventricular Ejection Fractio LVM = Left Ventricular Mass LVconc = Left Ventricular Concentricity (LVM/LVEDV) Published in Tadros, Francis et al, Nature Genetics 2020 : “Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.” (reference number: NG-LE54093). Full citation awaited. We performed a meta-analysis comprised of two strata. Subjects recruited and imaged in the North of England (Cheadle, Newcastle) were treated as the first stratum (n=15215 after exclusions) and those recruited in the South of England (Reading) comprised the second stratum (n=4045). For each stratum, BOLT-LMM (v2.3.2) was used to construct mixed models for association with around 9.5 million directly genotyped and imputed SNPs. Inverse-variance weighted meta-analysis was carried out with summary statistics from both strata using METAL (version released on 2011-03-25). For further details of methods, please see publication as above. Analyses undertaken by Rafik Tadros, Catherine Francis, ... Paul M Matthews and James S Ware et al. For summary stats from GWAS of HCM and DCM, please see https://heart-institute.nl/gwas
Files
| Filename | Size | Type | Description |
|---|---|---|---|
| LVEDV_metal.TBL.gz | 246MB | application/gzip | G-zipped tab-separated summary stats from METAL LVEDV |
| LVESV_metal.TBL.gz | 244MB | application/gzip | G-zipped tab-separated summary stats from METAL LVESV |
| LVM_metal.TBL.gz | 243MB | application/gzip | G-zipped tab-separated summary stats from METAL LVM |
| LVEF_metal.TBL.gz | 241MB | application/gzip | G-zipped tab-separated summary stats from METAL LVEF |
| LVconcentricity_metal.TBL.gz | 221MB | application/gzip | G-zipped tab-separated summary stats from METAL LVconc |
| LV_radial_strain_metal.TBL.gz | 242MB | application/gzip | G-zipped tab-separated summary stats from METAL LVradial strain |
| LV_longitudinal_strain_metal.TBL.gz | 238MB | application/gzip | G-zipped tab-separated summary stats from METAL LV longitudinal strain |
| LV_circumferential_strain_metal.TBL.gz | 239MB | application/gzip | G-zipped tab-separated summary stats from METAL LV circumferential strain |
| meanLVwallthickness_metal.TBL.gz | 232MB | application/gzip | G-zipped tab-separated summary stats from METAL LV mean wall thickness |
| README.txt | 680 | text/plain | README describing the headers and fields in the TBL.gz files |