Taming Brønsted Acid Reactivity: Nucleophilic Substitutions of Propargylic Alcohols with N-Nucleophiles Mediated by Phosphorus-Based Brønsted Acid Catalysts
DOI: 10.14469/hpc/5351 Metadata
Created: 2019-04-01 11:47
Last modified: 2024-11-27 17:13
License: Creative Commons: Public Domain Dedication 1.0
Funding: (none given)
Co-author: Lalita Radtanajiravong
Description
The activity of diethyl phosphite and diphenyl phosphate in propargylation reactions with N-nucleophiles of varying basicity is presented. Careful choice of the reaction conditions minimised undesired rearrangements and arylation processes, typical side reactions with Brønsted acid catalysis. These systems are compatible with technical solvents and presence of air and they are also applicable to C-, O- and S-nucleophiles.
Members
| DOI | Description |
|---|---|
| 10.14469/hpc/5352 | Propargylations - NMR Data |
Associated DOIs
| Current dataset ... | DOI | Description |
|---|---|---|
| References | 10.1021/acsomega.9b01427 | Published reference |