Karim Bahou - ISOM XXII - The Beneficial Use of Prenyl Groups in Ring-Closing Metathesis
DOI: 10.14469/hpc/2713 Metadata
Created: 2017-07-07 13:12
Last modified: 2019-02-05 16:48
License: Creative Commons: Public Domain Dedication 1.0
Funding: (none given)
Co-author: D. Christopher Braddock
Description
The prenyl moiety is present in vast numbers of naturally occurring compounds. Many of these are commercially available and very cheap, therefore, if they can be incorporated as a building block for organic syntheses, they can add great value. Furthermore, the synthesis of more structurally complex natural products, particularly those with a terpenoid framework, may proceed via compounds that contain the prenyl grouping. A plethora of metathesis reactions are used in natural product synthesis, despite this, there are relatively few examples of use of the prenyl moiety in olefin metathesis reactions, particularly in the synthesis of natural products. Using well established benchmarks for comparison, a thorough investigation and kinetic analysis into the use of the prenyl moiety in ring-closing metathesis will be presented and their utility in controlling the outcome of dienyne metathesis will be revealed.
Files
| Filename | Size | Type | Description |
|---|---|---|---|
| Karim Bahou - Poster.pdf | 1MB | application/pdf | |
| Karim Bahou - RCM (Graphs 1 - 6).pdf | 64KB | application/pdf | |
| Karim Bahou - Dienyne Metathesis (1H NMRs).pdf | 250KB | application/pdf | |
| Karim Bahou - ISOM XXII Abstract.pdf | 321KB | application/pdf |