NMR data for compound 8. tert-butyl 4-(quinolin-8-ylcarbamoyl)piperidine-1-carboxylate

DOI: 10.14469/hpc/14714 Metadata

Created: 2024-11-01 15:17

Last modified: 2024-11-05 17:56

Author: Henry Rzepa

License: Creative Commons: Public Domain Dedication 1.0

Funding: (none given)

Description

Synthesised according to the general procedure. Purified by flash column chromatography (EtOAc : Cyclohexane 10% à 50%). Yield = 1.38g brown solid, 3.88 mmol, 78%. Analytical data is in accordance with literature reports.7 1H NMR (700 MHz, CDCl3) δ (ppm) = 9.94 (s, 1H), 8.80 (dd, J = 4.2, 1.4 Hz, 1H), 8.77 (dd, J = 7.4, 0.9 Hz, 1H), 8.16 (dd, J = 8.2, 1.4 Hz, 1H), 7.53 (t, J = 7.8 Hz, 1H), 7.50 (dd, J = 8.1, 1.2 Hz, 1H), 7.46 (dd, J = 8.3, 4.2 Hz, 1H), 4.22 (br s, 2H), 2.86 (br s, 2H), 2.62 (tt, J = 11.5, 3.7 Hz, 1H), 2.03 (d, J = 11.3 Hz, 2H), 1.83 (qd, J = 12.2, 3.6 Hz, 2H), 1.48 (s, 9H) 13C NMR (176 MHz, CDCl3) δ (ppm) = 173.1, 154.9, 148.3, 138.6, 136.6, 134.5, 128.1, 127.6, 121.8, 121.7, 116.7, 79.8, 44.9, 43.8, 43.1, 28.9, 28.6. HRMS [C20H25N¬3O3+H]+: Calculated 356.1969, Observed 356.1964 Melting point: 103 – 105 °C

Member of collection / collaboration

DOIDescription
10.14469/hpc/14635 Borate-Catalysed Direct Amidation Reactions of Coordinating Substrates. NMR data

Members

DOIDescription
10.14469/hpc/14757 NMR data for compound 8. tert-butyl 4-(quinolin-8-ylcarbamoyl)piperidine-1-carboxylate. 1H
10.14469/hpc/14758 NMR data for compound 8. tert-butyl 4-(quinolin-8-ylcarbamoyl)piperidine-1-carboxylate. 13C

Subject Keywords

KeywordValue
Inchi InChI=1S/C20H25N3O3/c1-20(2,3)26-19(25)23-12-9-15(10-13-23)18(24)22-16-8-4-6-14-7-5-11-21-17(14)16/h4-8,11,15H,9-10,12-13H2,1-3H3,(H,22,24)
Inchikey LNAFEPBTQOWQAY-UHFFFAOYSA-N

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