“Angular” spirocyclic azetidines: synthesis, characterization, and evaluation in drug discovery
DOI: 10.14469/hpc/13611 Metadata
Created: 2024-01-14 14:05
Last modified: 2024-12-03 08:29
License: Creative Commons: Public Domain Dedication 1.0
Funding: (none given)
Co-author: Pavel Mykhailiuk
Description
The previously neglected “angular” spirocyclic azetidines have been synthesized, characterized, and validated in drug discovery. We have shown that these compounds could act as bioisosteres for common saturated six-membered heterocycles. Their incorporation into the structure of the anticancer drug Sonidegib (instead of morpholine), and Danofloxacine (instead of piperazine) provided novel patent-free analogs with similar physicochemical properties and high activity.
Members
| DOI | Description |
|---|---|
| 10.14469/hpc/13647 | Spirocyclic-azetidines, R = COEt |
| 10.14469/hpc/13644 | Spirocyclic azetidines, R = Me |
| 10.14469/hpc/13645 | Spirocyclic-azetidines, R = t-Butyl |
| 10.14469/hpc/13625 | Chlorosulfonyl isocyanate, G = -1177.111803 |
| 10.14469/hpc/13664 | Spirocyclic azetidines, R = Trifluoromethyl |
| 10.14469/hpc/13681 | FAIR Data Table. Activation energies and Geometries for“Angular” spirocyclic azetidines: synthesis, characterization, and evaluation in drug discovery. |
| 10.14469/hpc/14602 | “Angular” spirocyclic azetidines: synthesis, characterization, and evaluation in drug discovery. Dispersion contributions |
| 10.14469/hpc/13691 | Spirocyclic-azetidines, R = CO2Et |
| 10.14469/hpc/13646 | Spirocyclic-azetidines, R = OCH2Ph (Benzyl) |
Associated DOIs
| Current dataset ... | DOI | Description |
|---|---|---|
| References | 10.1002/anie.202418850 | Published article: “Angular” Spirocyclic Azetidines: Synthesis, Characterization, and Evaluation in Drug Discovery |
| isReferencedBy | 10.1002/anie.202418850 | Published article: “Angular” Spirocyclic Azetidines: Synthesis, Characterization, and Evaluation in Drug Discovery |