Straightforward and Efficient Deuteration of Terminal Alkynes with Copper Catalysis
DOI: 10.14469/hpc/12314 Metadata
Created: 2023-02-27 20:33
Last modified: 2024-11-27 17:00
License: Creative Commons: Public Domain Dedication 1.0
Funding: (none given)
Co-author: Silvia Diez-Gonzalez
Description
The mild and effective preparation of deuterated organic molecules is an active area of research due to their important applications. Herein, we report an air-stable and easy to access copper(I) complex as catalyst for the deuteration of mono-substituted alkynes. Reactions were carried out in technical solvents and in the presence of air, to obtain excellent deuterium incorporation in a range of functionalized alkynes.
Members
| DOI | Description |
|---|---|
| 10.14469/hpc/12319 | 1a-D, 1-Deutero-oct-1-yne |
| 10.14469/hpc/12323 | 1e-D, 4-Deutero-2-methylbut-3-yn-2-ol |
| 10.14469/hpc/12324 | 1f-D, 3-Deutero-1,1-diphenylprop-2-yn-1-ol |
| 10.14469/hpc/12326 | 1h-D, Deutero(trimethylsilyl)acetylene |
| 10.14469/hpc/12320 | 1b-D, 1,8-Deutero-octa-1,7-diyne |
| 10.14469/hpc/12321 | 1c-D, 5-Chloro-1-deutero-pent-1-yne |
| 10.14469/hpc/12322 | 1d-D, 5-Deuterohex-5-yn-1-ol |
| 10.14469/hpc/12325 | 1g-D, 1-Deutero-ethynyl-1-cyclohexanol |
| 10.14469/hpc/12327 | 1i-D, Deutero(triphenylsilyl)acetylene |
| 10.14469/hpc/12328 | 1j-D, 3-Deutero N,N-diethyl-prop-2-ynyl amine |
| 10.14469/hpc/12329 | 1k-D, Tris(prop-2-ynyl-3-deutero)amine |
| 10.14469/hpc/12330 | 1l-D, 2-(Prop-2-ynyl-3-deutero)isoindoline-1,3-dione |
| 10.14469/hpc/12331 | 1m-D, Phenyl(prop-2-ynyl-3-deutero)sulfane |
| 10.14469/hpc/12333 | 1n-D, Ethyl Deuteropropiolate |
| 10.14469/hpc/12334 | 1o-D, Dimethyl-2-(3-deutero-prop-2-ynyl) (deutero)malonate |
| 10.14469/hpc/12335 | 1p-D, 1-Deutero-3,3-diethoxyprop-1-yne |
| 10.14469/hpc/12336 | 1q-D, 1-Deutero-p-tolylacetylene |
| 10.14469/hpc/12337 | 1r-D, 1-Deutero-p-anisylacetylene |
| 10.14469/hpc/12338 | 1s-D, 1-Bromo-4-(deuteroethynyl)-benzene |
| 10.14469/hpc/12339 | 1t-D, 1,3-Bis(deuteroethynyl)benzene |
| 10.14469/hpc/12340 | 1u-D, 3-(Deuteroethynyl)pyridine |
| 10.14469/hpc/12341 | 1v-D, 2-(Deuteroethynyl)pyridine |
Associated DOIs
| Current dataset ... | DOI | Description |
|---|---|---|
| References | 10.3390/catal13040648 | Published reference |