Functionalization and Hydrogenation of Carbon Chains Derived from CO
DOI: 10.14469/hpc/10042 Metadata
Created: 2021-12-18 13:42
Last modified: 2022-01-09 14:10
License: Creative Commons: Public Domain Dedication 1.0
Funding: (none given)
Co-author: Andrew White Co-author: Mark Crimmin Co-author: Richard Yuze Kong
Description
Selective reactions that combine H2, CO and organic electrophiles (aldehyde, ketones, isocyanide) to form hydrogenated C3 and C4 carbon chains are reported. These reactions proceed by CO homologation mediated by [W(CO)6] and an alumi-num(I) reductant, followed by functionalization and hydrogenation of the chain ends. A combination of kinetics (rates, KIEs) and DFT calculations has been used to gain insight into a key step which involves hydrogenation of a metallocar-bene intermediate. These findings expand the extremely small scope of systems that combine H2 and CO to make well-defined products with complete control over chain length and functionality.
Associated DOIs
| Current dataset ... | DOI | Description |
|---|---|---|
| References | 10.14469/hpc/10039 | xyz coordinates |
| References | 10.14469/hpc/10040 | NMR Data |
| References | 10.14469/hpc/10041 | IR Data |